The train was on its way from Cairo to the Nile Delta city of Mansoura when four carriages derailed some 40 kilometres north of Cairo, according to Egyptian National Railways in a brief statement.
The cause of the crash is being investigated, according to the statement.
According to the health ministry, more than 50 ambulances transported the wounded to three hospitals in the province.
The derailment is the most recent of many recent train accidents in Egypt. In March, two trains collided near Tahta, about 440 kilometres south of Cairo, killing at least 20 people and injuring nearly 200 others.
This month, two train carriages derailed near Minya al-Qamh district, about 70 kilometres north of Cairo, injuring fifteen people.
Egypt’s transportation minister, Kamel El-Wazir, a retired army officer, has faced calls to resign on social media from Egyptians.
He has denied them and has promised to continue working on improving the ageing rail network.