A clinical trial suggests that an experimental medicine could reduce the frequency of migraines.

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A novel migraine-prevention drug looks to be effective, according to a new clinical trial.

According to the study, atogepant reduced migraine days in patients by half after 12 weeks of treatment without producing major adverse effects.

According to experts, if approved by the US Food and Medicine Administration, the drug would provide migraine sufferers with a welcome new choice.

“There’s a great need for new preventive medications,” said Dr. Charles Flippen, a professor of clinical neurology at the University of California-Los Angeles.

In the United States alone, more than 37 million people suffer from migraines, according to the American Migraine Foundation. Besides intense head pain, the condition often causes symptoms like nausea, visual disturbances, and sensitivity to light and sound.

Doctors have long prescribed a number of oral medications for migraine prevention. The problem is, they are not “migraine-specific,” said Flippen, a fellow of the American Academy of Neurology who was not involved in the new study.

Instead, the drugs are borrowed from arsenals used to treat other conditions, including high blood pressure, depression and seizures. They can help prevent migraine attacks in some patients, but were not designed to target the condition.

Atogepant works by blocking cell receptors for CGRP, a small protein that is released by the trigeminal nerve during migraine attacks. It’s believed to play a key role in generating migraine misery.

Atogepant is not the first migraine drug to target CGRP, however. There are other “gepants” used for treating migraines-in-progress. And in May, one of them, rimegepant, had its approval expanded to include migraine prevention.

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There are also several CGRP inhibitors, all taken by injection, that have been approved for preventing migraines in the past several years.

“This is a very different time in headache medicine compared with a decade ago,” said Dr. Jessica Ailani, lead researcher on the new trial.

Having another preventive drug that targets CGRP, taken by pill, would give patients one more option.

“And that’s always good,” said Ailani, a clinical professor of neurology at MedStar Georgetown University Hospital, in Washington, D.C.

For the study, she and her colleagues recruited more than 900 migraine patients and randomly assigned them to one of four groups. One group received placebo (inactive) tablets, while the other three received different doses of atogepant.

Over 12 weeks, patients on the drug saw a bigger reduction in their migraines compared to the placebo group. On average, they went from having seven to eight “migraine” days per month, to three to four days.

“And quite a large portion of patients had a significant reduction,” Ailani said.

Of patients on the highest medication dose, 61% had at least a 50% drop in monthly migraine days over three months, the findings showed.

As for side effects, the most common issues were constipation and nausea, which affected about 15% of patients on the highest dose.

The study – published Aug. 19 in the New England Journal of Medicine – was funded by Allergan, the company that was developing atogepant before it was acquired by AbbVie.

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In March, AbbVie said the FDA had accepted its application to approve atogepant, and it expected a decision later this year.

Dr. Matthew Robbins, a neurologist at Weill Cornell Medicine and NewYork-Presbyterian in New York City, agreed that the more preventive options, the better.

“Migraine is so common, but so multifactorial, there’s never been a treatment that works well universally,” said Robbins, who reviewed the findings.

He pointed out that the study excluded those who suffer from persistent migraines, which occur at least 15 days each month. Injection CGRP inhibitors, according to Robbins, have been demonstrated to benefit these patients.

According to Ailani, atogepant is being researched for the prevention of chronic migraine.

Longer, larger investigations are still needed, according to all three specialists. One uncertainty, according to Robbins, is if some patients may experience uncommon medical consequences as a result of long-term treatment.

Because earlier preventative treatments have a lot of data behind them – and are available as low-cost generics – CGRP therapies are unlikely to become the primary choice for preventive treatment, he says.


But for patients who don’t respond to older drugs, or cannot tolerate the side effects, the newer “designer” medications offer an alternative, Robbins said.

All three doctors said they’d seen CGRP inhibitors work for long-time migraine sufferers who had failed to get relief from older treatments.

“There’s hope,” Ailani said. “Don’t give up.”


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