A clinical experiment will be conducted to investigate the mixing of brands in the COVID-19 vaccination and booster doses.

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The National Institutes of Health stated on Tuesday that a clinical trial has begun to examine the impact of people who have been completely vaccinated with one COVID-19 vaccination regimen receiving a booster dose of another regimen.

The trial will include 150 adults who will receive a single booster dose of the Moderna COVID-19 vaccine 12 to 20 weeks after they have received a full regimen of the Johnson & Johnson, Moderna and Pfizer vaccines.

Additionally, people who have not received a COVID-19 vaccine authorized by the Food and Drug Administration will be able to participate in the trial and will receive the two-dose Moderna vaccine regimen and a booster 12 to 20 weeks later.

Each vaccine group will include 25 people aged 18-55 and 25 people aged 56 and older.

“Although the vaccines currently authorized by the U.S. Food and Drug Administration offer strong protection against COVID-19, we need to prepare for the possibility of needing booster shots to counter waning immunity and to keep pace with the evolving virus,” said Dr. Anthony Fauci, director of the National Institute for Allergy and Infectious Diseases. “The results of this trial are intended to inform public health policy decisions on the potential use of mixed vaccine schedules should booster doses be indicated.”

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Participants in the study will be asked to complete telephone check-ins and in-person follow-ups as well as provide blood samples for one year after the study.

People who have received a full immunisation regimen can anticipate to need a booster within a year after their final dose, according to the three major vaccine producers in the United States.

Pfizer stated in April that a third dosage would most likely be necessary between six and twelve months after finishing the first two-shot regimen, and that vaccines would then be done yearly.

Moderna stated that their vaccine gives six months of protection and that it is working on a booster, but Johnson and Johnson stated that their single-shot vaccination will most likely need to be administered yearly.



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